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Rigid Amphiphiles for Membrane Protein Manipulation
Author(s) -
McQuade D. Tyler,
Quinn Mariah A.,
Yu Seungju M.,
Polans Arthur S.,
Krebs Mark P.,
Gellman Samuel H.
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000218)39:4<758::aid-anie758>3.0.co;2-v
Subject(s) - bacteriorhodopsin , rhodopsin , amphiphile , membrane , membrane protein , tripod (photography) , chemistry , biophysics , biochemistry , biology , organic chemistry , engineering , copolymer , retinal , polymer , mechanical engineering
The two nonhomologous membrane proteins bacteriorhodopsin and bovine rhodopsin can be extracted from their native membranes by the rigid tripod amphiphile 1 . Both proteins are maintained in a stable, soluble form, which is a prerequisite for crystallization. This new class of amphiphiles can be easily modified and could prove to be very useful for membrane protein manipulation.