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A p (O 2 )‐Responsive MRI Contrast Agent Based on the Redox Switch of Manganese( II / III ) – Porphyrin Complexes
Author(s) -
Aime Silvio,
Botta Mauro,
Gianolio Eliana,
Terreno Enzo
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000218)39:4<747::aid-anie747>3.0.co;2-2
Subject(s) - porphyrin , manganese , adduct , chemistry , magnetic resonance imaging , relaxation (psychology) , mri contrast agent , contrast (vision) , oxygen , redox , supramolecular chemistry , nuclear magnetic resonance , resonance (particle physics) , photochemistry , crystallography , inorganic chemistry , gadolinium , crystal structure , organic chemistry , physics , radiology , medicine , psychology , social psychology , particle physics , optics
Different relaxation rates of water protons are enhanced by a contrast agent for magnetic resonance imaging (MRI). A supramolecular adduct of poly‐ β ‐cyclodextrin and [(Mn II (tpps)] 4− is described. Oxidation of the manganese center to Mn III causes a marked decrease in the observed relaxivity r 1p (see scheme), which makes this a novel, functional MRI contrast agent for the measurement of partial pressures of oxygen. tpps=5,10,15,20‐Tetrakis‐( p ‐sulfonatophenyl) porphinate.