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Selenium‐Based Solid‐Phase Synthesis of Benzopyrans II: Applications to Combinatorial Synthesis of Medicinally Relevant Small Organic Molecules
Author(s) -
Nicolaou K. C.,
Cao GuoQiang,
Pfefferkorn Jeffrey A.
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000218)39:4<739::aid-anie739>3.0.co;2-z
Subject(s) - benzopyrans , combinatorial synthesis , solid phase synthesis , combinatorial chemistry , selenium , small molecule , phase (matter) , molecule , organic molecules , chemistry , organic synthesis , computer science , nanotechnology , materials science , organic chemistry , catalysis , peptide , biochemistry
A practical new strategy for solid‐phase chemistry and combinatorial synthesis has been developed. A collection of resin‐bound 2,2‐dimethylbenzopyran scaffolds have been constructed employing a novel selenium‐based simultaneous cyclization and loading (“cycloloading”) approach (see scheme). Selected scaffolds have been further elaborated to provide small combinatorial libraries of various natural products and designed molecules.