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Cationic Phosphonolipids Containing Quaternary Phosphonium and Arsonium Groups for DNA Transfection with Good Efficiency and Low Cellular Toxicity**
Author(s) -
Guénin Erwann,
Hervé AnneCécile,
Floch Virginie,
Loisel Séverine,
Yaouanc JeanJacques,
Clément JeanClaude,
Férec Claude,
des Abbayes Hervé
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000204)39:3<629::aid-anie629>3.0.co;2-k
Subject(s) - phosphonium , cationic polymerization , transfection , chemistry , solvent , dna , ammonium , polymer chemistry , organic chemistry , biochemistry , gene
Replacing the ammonium polar head in cationic lipids 1 (A=N) by a phosphonium or an arsonium group (A=P, As) improves their properties as synthetic vectors for DNA transfection. The increased volume of the cationic head is supposed to modify the interactions of the vector with the solvent and DNA.