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Identification of Toxic 2,4‐Decadienal in Oxidized, Low‐Density Lipoprotein by Solid‐Phase Microextraction
Author(s) -
Spiteller Dieter,
Spiteller Gerhard
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000204)39:3<583::aid-anie583>3.0.co;2-o
Subject(s) - hexanal , solid phase microextraction , chemistry , low density lipoprotein , chromatography , gas chromatography–mass spectrometry , biochemistry , mass spectrometry , cholesterol
The oxidation of low‐density lipoprotein (LDL) in vitro was studied by a combination of solid‐phase microextraction and GC/MS. 2‐ trans ,4‐ cis ‐2,4‐Decadienal, which is strongly toxic in vitro, was detected as the early oxidation product. This compound is degraded further to hexanal and (by cyclization of 4‐hydroxy‐2‐nonenal) to 2‐pentylfuran.