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Methylcorrinoids Methylate Radicals—Their Second Biological Mode of Action?
Author(s) -
Mosimann Hervé,
Kräutler Bernhard
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000117)39:2<393::aid-anie393>3.0.co;2-m
Subject(s) - radical , methylcobalamin , chemistry , schematic , methylation , stereochemistry , photochemistry , vitamin b12 , organic chemistry , biochemistry , electronic engineering , gene , engineering
An unprecedented methylation of alkyl radicals is possible with the diamagnetic vitamin B 12 derivative methylcobalamin (see schematic representation). Methylcorrinoids can thus also be considered as methylating cofactors in radical C‐methylations.