Premium
Efficient Hydrolysis of RNA by a PNA – Diethylenetriamine Adduct
Author(s) -
Verheijen Jeroen C.,
Deiman Birgit A. L. M.,
Yeheskiely Esther,
van der Marel Gijs A.,
van Boom Jacques H.
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000117)39:2<369::aid-anie369>3.0.co;2-a
Subject(s) - diethylenetriamine , adduct , peptide nucleic acid , nucleic acid , hydrolysis , chemistry , rna , sequence (biology) , stereochemistry , urea , peptide , biochemistry , organic chemistry , gene
The introduction of a urea bond linking a protected diethylenetriamine (DETA) unit and the terminal amino group of a resin‐bound peptide nucleic acid (PNA) decamer gave access to a PNA – DETA adduct (shown here), which hydrolyzed the target 25‐mer RNA rapidly and sequence specifically.