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Enantioselective Total Synthesis of Epothilone A Using Multifunctional Asymmetric Catalyses
Author(s) -
Sawada Daisuke,
Shibasaki Masakatsu
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000103)39:1<209::aid-anie209>3.0.co;2-f
Subject(s) - enantioselective synthesis , aldol reaction , total synthesis , chemistry , catalysis , stereochemistry , epothilones , combinatorial chemistry , epothilone , organic chemistry
A catalytic version has now been developed for the enantioselective total synthesis of epothilone A ( 1 ). The key is the use of multifunctional asymmetric catalyses for a direct aldol reaction and cyanosilylation. This successful approach demonstrated the usefulness of these reactions for the catalytic asymmetric synthesis of complex molecules.