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Acetamidoglycosylation with Glycal Donors: A One‐Pot Glycosidic Coupling with Direct Installation of the Natural C(2)‐ N ‐Acetylamino Functionality
Author(s) -
Di Bussolo Valeria,
Liu Jing,
Huffman, Jr. Larry G.,
Gin David Y.
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000103)39:1<204::aid-anie204>3.0.co;2-z
Subject(s) - glycal , chemistry , reagent , glycosylation , glycosidic bond , organic chemistry , combinatorial chemistry , catalysis , stereoselectivity , biochemistry , enzyme
Nitrogen transfer to glycals : A new method for direct C2‐aza‐glycosylation with glycal donors has been developed (see scheme), employing the new reagent combination of thianthrene‐ S ‐oxide and trifluoroacetic anhydride for glycal activation, in an overall one‐pot procedure.