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Immobilization of TADDOL with a High Degree of Loading on Porous Silica Gel and First Applications in Enantioselective Catalysis
Author(s) -
Heckel Alexander,
Seebach Dieter
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000103)39:1<163::aid-anie163>3.0.co;2-j
Subject(s) - enantioselective synthesis , moiety , porosity , catalysis , silica gel , lewis acids and bases , materials science , chemical engineering , chemistry , organic chemistry , combinatorial chemistry , polymer chemistry , chromatography , engineering
The versatile TADDOL moiety has been immobilized for the first time on an inorganic support (highly porous silica gel). This gives access to Ti – Lewis acids (see picture), which turn out to be very efficient in two standard enantioselective reactions. X=O i Pr, OTos.