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Carbohydrates Exhibit a Distinct Preferential Solvation Pattern in Binary Aqueous Solvent Mixtures
Author(s) -
Vishnyakov Aleksey,
Widmalm Göran,
Laaksonen Aatto
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000103)39:1<140::aid-anie140>3.0.co;2-2
Subject(s) - solvation , disaccharide , chemistry , solvation shell , aqueous solution , hydrogen bond , solvent , dimethyl sulfoxide , molecular dynamics , computational chemistry , organic chemistry , molecule
Molecular dynamics simulations reveal the entire solvation shell around a model disaccharide dissolved in the binary 1:3 molar mixture of dimethyl sulfoxide and water becomes distinctly structured (see drawing). Such preferential solvation is due to the large number of hydroxyl groups and the rich network of hydrogen bonds of a disaccharide formed with the solvent.