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Asymmetric Synthesis of the Nakijiquinones—Selective Inhibitors of the Her‐2/Neu Protooncogene
Author(s) -
Stahl Petra,
Waldmann Herbert
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19991216)38:24<3710::aid-anie3710>3.0.co;2-h
Subject(s) - enantioselective synthesis , chemistry , natural product , stereochemistry , total synthesis , derivative (finance) , ovary , ketone , combinatorial chemistry , biochemistry , endocrinology , biology , organic chemistry , catalysis , financial economics , economics
A Wieland–Miescher type ketone and a tetramethoxyaryl derivative are the key building blocks for the enantioselective total synthesis of nakijiquinone C ( 1 ). The nakijiquinones are the only natural products known that selectively inhibit the Her‐2/Neu tyrosine kinase, a protooncogene product that is vastly overexpressed in about 30 % of primary breast, ovary, and gastric carcinomas.