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Rolling Loop Scan: An Approach Featuring Ring‐Closing Metathesis for Generating Libraries of Peptides with Molecular Shapes Mimicking Bioactive Conformations or Local Folding of Peptides and Proteins
Author(s) -
Reichwein John F.,
Wels Bas,
Kruijtzer John A. W.,
Versluis Cees,
Liskamp Rob M. J.
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19991216)38:24<3684::aid-anie3684>3.0.co;2-m
Subject(s) - folding (dsp implementation) , metathesis , ring closing metathesis , closing (real estate) , loop (graph theory) , chemistry , solid phase synthesis , combinatorial chemistry , alkylation , ring (chemistry) , stereochemistry , amino acid , side chain , peptide , biochemistry , organic chemistry , mathematics , combinatorics , political science , law , electrical engineering , catalysis , polymerization , engineering , polymer
Libraries of loop‐containing peptides (such as the one shown schematically) can be prepared from bis‐N‐alkylated peptides by ring‐closing metathesis. In a general solid‐phase procedure the peptides are accessible by site‐specific N‐alkylation. Since the amino acid side chains are not involved in cyclization, they remain available for interaction with, for example, a receptor.