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New Efficient Multicomponent Reactions with C−C Coupling for Combinatorial Application in Liquid and on Solid Phase
Author(s) -
de Meijere Armin,
Nüske Hanno,
EsSayed Mazen,
Labahn Thomas,
Schroen Maarten,
Bräse Stefan
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19991216)38:24<3669::aid-anie3669>3.0.co;2-x
Subject(s) - coupling (piping) , phase (matter) , materials science , statistical physics , chemical physics , chemistry , physics , organic chemistry , metallurgy
Up to nine C−C bonds are formed selectively from up to seven components starting from an alkene, a haloarene, and a dienophile [Eq. (1)]. A comparison of liquid‐ and solid‐phase reactions reveals a surprising superiority of the solid‐phase reaction.