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Asymmetric Total Synthesis of Fluvirucinine A 1
Author(s) -
Suh YoungGer,
Kim SoonAi,
Jung JaeKyung,
Shin DongYun,
Min KyungHoon,
Koo BonAm,
Kim HwaSoon
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19991203)38:23<3545::aid-anie3545>3.0.co;2-0
Subject(s) - total synthesis , amide , stereochemistry , chemistry , enantioselective synthesis , claisen rearrangement , antibiotics , combinatorial chemistry , organic chemistry , biochemistry , catalysis
Diastereoselective vinyl addition to an amide carbonyl group and amide enolate induced aza‐Claisen rearrangement are the key steps in the first asymmetric total synthesis of fluvirucinine A 1 ( 1 ), the aglycon of fluvirucin A 1 . Fluvirucins are a class of macrolactam antibiotics produced by actinomycete strains that show promising biological properties.