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Development of New Chiral P,N Ligands and Their Application in the Cu‐Catalyzed Enantioselective Conjugate Addition of Diethylzinc to Enones
Author(s) -
Hu Xinquan,
Chen Huilin,
Zhang Xumu
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19991203)38:23<3518::aid-anie3518>3.0.co;2-p
Subject(s) - diethylzinc , conjugate , enantioselective synthesis , catalysis , chemistry , toluene , copper , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , mathematics , mathematical analysis
High enantioselectivity (up to 98 % ee ) has been achieved for the conjugate addition of diethylzinc to acyclic enones utilizing Cu I complexes of the novel chiral P,N ligands 1 . The high enantioselectivities are best achieved using [Cu(OTf)] 2 ⋅C 6 H 6 as the copper catalyst precursor in nonpolar solvents such as toluene or Cl(CH 2 ) 2 Cl. R=H, CH 3 ; Tf=F 3 CSO 2 .