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The First Catalytic Asymmetric Nitro‐Mannich‐Type Reaction Promoted by a New Heterobimetallic Complex
Author(s) -
Yamada Kenichi,
Harwood Simon J.,
Gröger Harald,
Shibasaki Masakatsu
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19991203)38:23<3504::aid-anie3504>3.0.co;2-e
Subject(s) - nitro , mannich reaction , catalysis , chemistry , type (biology) , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , biology , ecology , alkyl
The best ratio is 1:1:3 for the components Yb, K, and binaphthol in the new heterobimetallic complex, which efficiently catalyzes an asymmetric nitro‐Mannich‐type reaction. The desired nitro‐Mannich products 2 are obtained with up to 91 % ee starting from N ‐phosphinoyl imines 1 .