Premium
Reductive Activation of a Hydroxylamine Hemiacetal Derivative of Dehydromonocrotaline: The First Reductively Activated Pyrrolizidine Alkaloid Capable of Cross‐Linking DNA
Author(s) -
Tepe Jetze J.,
Williams Robert M.
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19991203)38:23<3501::aid-anie3501>3.0.co;2-w
Subject(s) - pyrrolizidine , pyrrolizidine alkaloid , dna , hydroxylamine , alkaloid , chemistry , stereochemistry , cytotoxicity , hemiacetal , derivative (finance) , biochemistry , in vitro , economics , financial economics
The acute hepatotoxicity displayed by the pyrrolizidine alkaloids, which obviates their clinical utility, is a result of activation in vivo by cytochrome P450 mediated oxidation. Now the first reductively activated progenitor of the highly cytotoxic dehydropyrrolizidine alkaloid dehydromonocrotaline has been synthesized and demonstrated to mediate interstrand DNA cross‐link formation (see scheme); pyrrolizidine alkaloids exert their cytotoxicity through the formation of DNA–DNA interstrand and DNA–protein cross‐links.