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A Two‐Directional and Highly Convergent Approach for the Synthesis of the Tumor‐Associated Antigen Globo‐H
Author(s) -
Zhu Tong,
Boons GeertJan
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19991203)38:23<3495::aid-anie3495>3.0.co;2-x
Subject(s) - glycosylation , antigen , chemistry , protecting group , microbiology and biotechnology , biochemistry , biology , immunology , organic chemistry , alkyl
The assembly of six readily available building blocks in five glycosylation steps affords the tumor‐associated Globo‐H hexasaccharide 1 without the need for any intermediate protecting group manipulations. The aminopropyl spacer is employed for conjugation to carrier proteins.