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The First Catalytic Enantioselective Nozaki–Hiyama Reaction
Author(s) -
Bandini Marco,
Cozzi Pier Giorgio,
Melchiorre Paolo,
UmaniRonchi Achille
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19991115)38:22<3357::aid-anie3357>3.0.co;2-w
Subject(s) - enantioselective synthesis , catalysis , chemistry , organic chemistry , combinatorial chemistry
The Nozaki–Hiyama reaction can be performed in an enantioselective catalytic way! The catalytic system utilizes 10 mol % of an inexpensive chiral [Cr(salen)] complex. The [Cr(salen)]/Mn/Me 3 SiCl system effectively promotes the enantioselective addition of allyl chloride to aliphatic and aromatic aldehydes at room temperature (65–89 % ee , 40–60 % yield).