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Discovery of Novel Catalysts for Allylic Alkylation with a Visual Colorimetric Assay
Author(s) -
Lavastre Olivier,
Morken James P.
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19991102)38:21<3163::aid-anie3163>3.0.co;2-#
Subject(s) - tsuji–trost reaction , alkylation , catalysis , chemistry , combinatorial chemistry , allylic rearrangement , organic chemistry
The first non‐phosphane iridium catalyst , made from [{IrCl(cod)} 2 ] and i Pr‐pybox (shown schematically; cod=1,5‐cyclooctadiene), for allylic alkylation in neutral medium was discovered by a simple, rapid, and inexpensive screening assay. The red coloration upon treatment of the reaction mixtures with Fast Red (see the 96‐well plate) indicates the presence of 1‐naphthol and thus the occurrence of allylic alkylation.