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α ‐Alkyl‐ α ‐Amino‐ β ‐Lactam Peptides: Design, Synthesis, and Conformational Features
Author(s) -
Palomo Claudio,
Aizpurua Jesus M.,
Benito Ana,
Galarza Regina,
Khamrai Uttam K.,
Vazquez Jordi,
de PascualTeresa Beatriz,
Nieto Pedro M.,
Linden Anthony
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19991018)38:20<3056::aid-anie3056>3.0.co;2-j
Subject(s) - peptidomimetic , lactam , alkylation , alkyl , chemistry , stereochemistry , lithium (medication) , peptide , combinatorial chemistry , biology , biochemistry , organic chemistry , catalysis , endocrinology
Remarkable asymmetric induction is achieved in the alkylation of the lithium enolate of the β ‐lactam 1 . This allows the first time access to a new family of peptidomimetics 2 with predictable conformational constraints.