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Natural Product Synthesis on Polymeric Supports—Synthesis and Biological Evaluation of an Indolactam Library
Author(s) -
Meseguer Benjamin,
AlonsoDíaz Daniel,
Griebenow Nils,
Herget Thomas,
Waldmann Herbert
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19991004)38:19<2902::aid-anie2902>3.0.co;2-2
Subject(s) - amination , indole test , regioselectivity , natural product , enantioselective synthesis , chemistry , combinatorial chemistry , ring (chemistry) , stereochemistry , solid phase synthesis , indole alkaloid , biochemistry , peptide , organic chemistry , catalysis
Abstract Potent activators of protein kinase C in fibroblasts: This property was determined for several indolactam V analogues ( 1 ) with a new cell‐based assay system. This tumor‐promoting indole alkaloid and analogues thereof can be synthesized efficiently on the solid phase. The key steps of the combinatorial approach are a regioselective amination of the indole ring and an enantioselective enzymatic reaction.