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Novel Fluorescent Probes for Singlet Oxygen
Author(s) -
Umezawa Naoki,
Tanaka Kumi,
Urano Yasuteru,
Kikuchi Kazuya,
Higuchi Tsunehiko,
Nagano Tetsuo
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19991004)38:19<2899::aid-anie2899>3.0.co;2-m
Subject(s) - fluorescence , singlet oxygen , photochemistry , oxygen , chemistry , yield (engineering) , superoxide , nitric oxide , materials science , biochemistry , organic chemistry , optics , physics , metallurgy , enzyme
The first fluorescent chemical traps for 1 O 2 have been developed. DPAXs react specifically with 1 O 2 to yield the corresponding endoperoxides, DPAX‐EPs (see scheme; X = H, Cl, F). DPAXs scarcely fluoresce, while DPAX‐EPs are strongly fluorescent. Since the fluorescence of these probes is unaffected by H 2 O 2 , superoxide, and nitric oxide, they are useful for the selective detection of 1 O 2 in biological systems.