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Transfer Catalysis Between Two Solids: Application to the Reduction of Nitroarenes
Author(s) -
Hari Anitha,
Miller Benjamin L.
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990917)38:18<2777::aid-anie2777>3.0.co;2-x
Subject(s) - chemistry , catalysis , redox , solid acid , nitro , trimethylsilyl , chromium , combinatorial chemistry , phase (matter) , solid solution , selective catalytic reduction , inorganic chemistry , organic chemistry , alkyl
A wide range of aromatic nitro compounds can be reduced to anilines through the use of a Cr II /Mn 0 redox couple in the presence of trimethylsilyl chloride [TMSCl, Eq. (1)]. Only 0.25 equivalents of chromium are required to reduce solid‐supported nitroarenes (R=solid support); this represents a rare case of transfer catalysis between two solid phases. The reaction is also amenable to solution‐phase synthesis (R=OH).