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4‐[3,5‐Bis(2‐hydroxyphenyl)‐1,2,4‐triazol‐1‐yl]‐ benzoic Acid: A Novel Efficient and Selective Iron( III ) Complexing Agent
Author(s) -
Heinz Uwe,
Hegetschweiler Kaspar,
Acklin Pierre,
Faller Bernard,
Lattmann René,
Schnebli Hans Peter
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990903)38:17<2568::aid-anie2568>3.0.co;2-c
Subject(s) - ligand (biochemistry) , benzoic acid , chemistry , chelation , combinatorial chemistry , stereochemistry , inorganic chemistry , organic chemistry , receptor , biochemistry
An exceptionally stable 1:2 complex [FeL 2 ] 3− is formed from the ligand H 3 L and Fe III . In contrast, the affinity of this ligand for other biometals is relatively small. These properties make H 3 L a highly promising candidate for medical applications (e.g. for the treatment of iron overload).