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The First General Method for Stille Cross‐Couplings of Aryl Chlorides
Author(s) -
Littke Adam F.,
Fu Gregory C.
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990816)38:16<2411::aid-anie2411>3.0.co;2-t
Subject(s) - stille reaction , aryl , reagent , chemistry , combinatorial chemistry , organic chemistry , polymer , alkyl
A “one‐two punch” comprising two commercially available reagents, P t Bu 3 and CsF, provides a practical and general solution for a long‐standing limitation of the Stille reaction—the inability to couple inexpensive and readily available aryl chlorides [Eq. (1); R 1 =OMe, NH 2 , o ‐Me, etc.; R=vinyl, allyl, Ph, Bu, etc.].