Premium
Integrated Chemical Process: One‐Pot Aromatization of Cyclic Enones by the Double Elimination Methodology
Author(s) -
Orita Akihiro,
Yaruva Jayamma,
Otera Junzo
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990802)38:15<2267::aid-anie2267>3.0.co;2-3
Subject(s) - aromatization , chemistry , organic chemistry , alkyl , friedel–crafts reaction , aromaticity , reaction conditions , combinatorial chemistry , molecule , catalysis
A variety of aromatic hydrocarbons bearing multiple alkyl substituents are accessible with perfect regiocontrol in a one‐pot reaction starting from cyclohexenones and their aromatic analogues [Eq. (1)]. The present methodology can be further extended to the synthesis of polycyclic aromatic hydrocarbons. The drawbacks encountered in the Friedel–Crafts reaction are resolved since the reaction proceeds under basic conditions.