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A Convergent Strategy for the Modification of Peptide Nucleic Acids: Novel Mismatch‐Specific PNA‐Hybridization Probes
Author(s) -
Seitz Oliver,
Bergmann Frank,
Heindl Dieter
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990802)38:15<2203::aid-anie2203>3.0.co;2-2
Subject(s) - peptide nucleic acid , nucleobase , nucleic acid , combinatorial chemistry , chemistry , peptide , dna , nucleic acid thermodynamics , fluorescence , conjugate , biochemistry , base sequence , physics , quantum mechanics , mathematical analysis , mathematics
Coupling of nonnatural nucleobases to the orthogonally protected backbone 1 on the solid phase provided access to novel peptide nucleic acid (PNA) conjugates 2 , which are difficult to synthesize by standard routes. Hybridization probes containing the thiazolorange dye might allow DNA sequence analysis in real time. B−CH 2 CO=modified nucleobase, fluorescent dye, etc; Boc, Fmoc=protecting groups.