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A New Platinum Anticancer Drug Forms a Highly Stereoselective Adduct with Duplex DNA
Author(s) -
Chen Yu,
Parkinson John A.,
Guo Zijian,
Brown Tom,
Sadler Peter J.
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990712)38:13/14<2060::aid-anie2060>3.0.co;2-j
Subject(s) - duplex (building) , anticancer drug , stereoselectivity , stereochemistry , chemistry , dna , drug , schematic , adduct , combinatorial chemistry , computational biology , biology , biochemistry , pharmacology , organic chemistry , catalysis , electronic engineering , engineering
The alignment of the 2‐picoline ligand within the major groove contributes to the formation of a highly stereoselective GG intrastrand bischelate between the new anticancer drug cis ‐[PtCl 2 (NH 3 )(2‐picoline)] and a 14‐mer DNA duplex (see schematic representation).