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Interaction of a PDZ Protein Domain with a Synthetic Library of All Human Protein C Termini
Author(s) -
Hoffmüller Ulrich,
Russwurm Michael,
Kleinjung Frank,
Ashurst Jennifer,
Oschkinat Hartmut,
VolkmerEngert Rudolf,
Koesling Doris,
SchneiderMergener Jens
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990712)38:13/14<2000::aid-anie2000>3.0.co;2-v
Subject(s) - pdz domain , domain (mathematical analysis) , representation (politics) , peptide library , schematic , chemistry , computational biology , biochemistry , peptide sequence , biology , engineering , mathematical analysis , mathematics , gene , electronic engineering , politics , political science , law
New interaction partners of a PDZ protein domain were identified through use of a library made up of all known human protein C‐terminal peptides (“P” in the schematic representation). The library was displayed on a cellulose membrane by positional resolution of inverted peptides.