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Identification of Sequence‐Selective Receptors for Peptides with a Carboxylic Acid Terminus
Author(s) -
Fessmann Thilo,
Kilburn Jeremy D.
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990712)38:13/14<1993::aid-anie1993>3.0.co;2-h
Subject(s) - receptor , peptide , sequence (biology) , peptide sequence , chemistry , n terminus , carboxylic acid , combinatorial chemistry , computational biology , biochemistry , stereochemistry , biology , gene
A combinatorial library of “tweezer” receptors , which incorporate a diamidopyridine unit to provide a specific binding site for a CO 2 H group (see picture), can be screened to identify sequence‐selective receptors for chosen peptide guests with a CO 2 H terminus.