Premium
New Advances in the Biosynthesis of Glycopeptide Antibiotics of the Vancomycin Type from Amycolatopsis mediterranei
Author(s) -
Süssmuth Roderich D.,
Pelzer Stefan,
Nicholson Graeme,
Walk Tilmann,
Wohlleben Wolfgang,
Jung Günther
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990712)38:13/14<1976::aid-anie1976>3.0.co;2-3
Subject(s) - glycopeptide , glycopeptide antibiotic , biosynthesis , vancomycin , antibiotics , chemistry , mutant , microbiology and biotechnology , biochemistry , stereochemistry , biology , bacteria , enzyme , gene , staphylococcus aureus , genetics
Linear biosynthesis products from balhimycin , a tricyclic glycopeptide antibiotic of the vancomycin type, were isolated from mutants of Amycolatopsis mediterranei . The structures of these intermediates, determined by NMR spectroscopy, give new impulses for the understanding of the vancomycin biosynthesis.