Premium
Nitric Oxide: A Unique Endogenous Signaling Molecule in Vascular Biology (Nobel Lecture)
Author(s) -
Ignarro Louis J.
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990712)38:13/14<1882::aid-anie1882>3.0.co;2-v
Subject(s) - nitric oxide , endogeny , endothelium derived relaxing factor , endothelium , cyclic gmp , neuroscience , microbiology and biotechnology , chemistry , biology , biophysics , biochemistry , endocrinology
“Endothelium‐derived relaxing factor (EDRF) must be nitric oxide.” Although there was much experimental evidence that effects on or actions of EDRF were identical to those of nitric oxide, proposing this hypothesis certainly meant going out on a limb. However, once this discovery was made increased investigation indicated the physiological significance of nitric oxide in vascular biology.