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Solid‐Phase Synthesis of Thio‐oligosaccharides
Author(s) -
Hummel Gerd,
Hindsgaul Ole
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990614)38:12<1782::aid-anie1782>3.0.co;2-1
Subject(s) - thio , sugar , yield (engineering) , chemistry , polymer , protecting group , solid phase synthesis , phase (matter) , organic chemistry , combinatorial chemistry , polymer chemistry , biochemistry , materials science , peptide , alkyl , metallurgy
No protecting groups are present in the highly reactive polymer‐bound sugar 1‐thiolates 1 , which undergo reactions with sugar triflates 2 to give thio‐oligosaccharides 3 in high yield. Tr=trityl=triphenylmethyl, Tf=trifluoromethylsulfonyl, Bz=benzoyl.