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A Method for High‐Throughput Screening of Enantioselective Catalysts
Author(s) -
Reetz Manfred T.,
Becker Michael H.,
Klein HeinzWerner,
Stöckigt Detlef
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990614)38:12<1758::aid-anie1758>3.0.co;2-8
Subject(s) - enantioselective synthesis , chemistry , catalysis , enantiomer , electrospray ionization , mass spectrometry , stoichiometry , hydrolysis , enantiomeric excess , combinatorial chemistry , electrospray , chirality (physics) , organic chemistry , chromatography , chiral symmetry breaking , physics , quantum mechanics , quark , nambu–jona lasinio model
About 1000 catalytic or stoichiometric asymmetric reactions of racemic compounds or prochiral substrates bearing enantiotopic groups can be analyzed per day. In this highly efficient method the enantioselectivity is determined by electrospray ionization mass spectrometry using isotopically labeled substrates. The picture shows the mass spectrum of the mixture obtained upon hydrolysis of 1 to afford the pseudo ‐enantiomeric products 2 and 3 .