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Total Synthesis of the CP Molecules CP‐263,114 and CP‐225,917— Part 1: Synthesis of Key Intermediates and Intelligence Gathering
Author(s) -
Nicolaou K. C.,
Baran Phil S.,
Zhong YongLi,
Choi HaSoon,
Yoon Won Hyung,
He Yun,
Fong Kin Chiu
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990601)38:11<1669::aid-anie1669>3.0.co;2-d
Subject(s) - key (lock) , combinatorial chemistry , molecule , computer science , nanotechnology , chemistry , materials science , organic chemistry , computer security
A synthetic labyrinth endowed with countless obstacles, yet filled with numerous hidden treasures, had to be overcome to reach the CP molecules CP‐263,114 ( 1 ) and CP‐225,917 ( 2 ). Their complex molecular frameworks coupled with the array of sensitive functionalities present amount to a formidable synthetic challenge. Moreover, these compounds possess interesting biological properties. Although the first synthetic strategies ended before the goals were achieved, in spite of careful preparation and numerous model studies, enough information was gathered en route to enable a revised approach to be formulated, which finally culminated in success.