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RNA and the Small Molecule World
Author(s) -
Tor Yitzhak
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990601)38:11<1579::aid-anie1579>3.0.co;2-h
Subject(s) - rna , messenger rna , computational biology , small molecule , riboswitch , gene expression , microbiology and biotechnology , chemistry , biology , non coding rna , gene , genetics
A key role in essential cellular processes is played by RNA molecules, and these are attractive targets for drug design. The functional diversity of RNA can be attributed to the sophisticated three‐dimensional structures it assumes. These intricate folds create potential binding pockets for ions, low molecular weight ligands, and proteins. Recent experiments have demonstrated that small molecules such as tobramycin ( 1 ) can regulate gene expression in living cells through specific interactions with a messenger RNA (mRNA).