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Metals in Medicine
Author(s) -
Guo Zijian,
Sadler Peter J.
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990601)38:11<1512::aid-anie1512>3.0.co;2-y
Subject(s) - ruthenium , chemistry , gadolinium , vanadium , paramagnetism , ligand (biochemistry) , lanthanide , combinatorial chemistry , radiochemistry , inorganic chemistry , ion , biochemistry , organic chemistry , catalysis , physics , receptor , quantum mechanics
Not only the 24 or so essential elements , but also nonessential and even radioactive elements have enormous potential for applications in medicine. In the fight against cancer cisplatin, one of the world's best selling anticancer drugs, is being joined by other platinum, titanium, and ruthenium complexes. Gadolinium( III ) complexes can be safely injected as magnetic resonance imaging contrast agents, and ligand design allows targeting of paramagnetic ions as well as radiodiagnostic (e.g. 99m Tc) and radiotherapeutic isotopes (e.g. 186 Re). Manganese superoxide dismutase mimics, vanadium insulin mimics, ruthenium nitric oxide scavengers, lanthanide‐based photosensitizers, and metal‐targeted organic agents show exciting clinical potential.