Premium
Cesium Hydroxide: A Superior Base for the Catalytic Alkynylation of Aldehydes and Ketones and Catalytic Alkenylation of Nitriles
Author(s) -
Tzalis Dimitrios,
Knochel Paul
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990517)38:10<1463::aid-anie1463>3.0.co;2-h
Subject(s) - alkynylation , catalysis , propargyl , acetonitrile , chemistry , hydroxide , caesium , base (topology) , organic chemistry , mathematical analysis , mathematics
The efficient addition of terminal alkynes to aldehydes or ketones to give propargyl alcohols in yields of 66–96 % can be achieved by activation with catalytic amounts of CsOH⋅H 2 O [Eq. (a)]. A CsOH‐catalyzed addition of acetonitrile derivatives to terminal alkynes is also possible.