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New Tripodal, “Supercharged” Analogues of Adenosine Nucleotides: Inhibitors for the Fhit Ap 3 A Hydrolase
Author(s) -
Liu Xiaohai,
Brenner Charles,
Guranowski Andrzej,
Starzynska Elzbieta,
Blackburn G. Michael
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990503)38:9<1244::aid-anie1244>3.0.co;2-0
Subject(s) - nucleotide , fhit , chemistry , adenosine , stereochemistry , biochemistry , hydrolase , enzyme , gene , tumor suppressor gene , carcinogenesis
Methanetrisphosphonic acids provide a branch point for synthetic nucleotide analogues which can be exploited either to generate novel tripodal nucleotides or to incorporate additional negative charge into linear analogues relative to the parent nucleotide, as exemplified in the picture for ATP and diadenosine tetraphosphate (Ap 4 A). These compounds show valuable discriminatory behavior as competitive inhibitors for the tumor suppressor protein Fhit and a second Ap n A pyrophosphohydrolase. X=H, Cl, F.