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Synthesis and Biological Evaluation of a Cyclo‐ β ‐tetrapeptide as a Somatostatin Analogue
Author(s) -
Gademann Karl,
Ernst Martin,
Hoyer Daniel,
Seebach Dieter
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990503)38:9<1223::aid-anie1223>3.0.co;2-a
Subject(s) - tetrapeptide , peptidomimetic , somatostatin , chemistry , somatostatin receptor , peptide , proteases , bioavailability , cyclic peptide , peptide hormone , receptor , biochemistry , stereochemistry , combinatorial chemistry , pharmacology , biology , endocrinology , enzyme
Short β ‐peptides can mimic natural peptide hormones , as has been shown with a cyclo‐ β ‐tetrapeptide ( 1 ) that displays micromolar affinity to human somatostatin receptors. β ‐Peptides are thus a promising new class of peptidomimetics with potential high bioavailability due to their excellent resistance against proteases.