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Discovery of Novel Catalysts for Alkene Epoxidation from Metal‐Binding Combinatorial Libraries
Author(s) -
Francis Matthew B.,
Jacobsen Eric N.
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990401)38:7<937::aid-anie937>3.0.co;2-o
Subject(s) - catalysis , epoxide , olefin fiber , ligand (biochemistry) , combinatorial chemistry , alkene , enantioselective synthesis , chemistry , metal , organic chemistry , biochemistry , receptor
New lead structures for olefin oxidation catalysts have been obtained from a combinatorial library of 5760 metal–ligand complexes (see the microscopy picture). Iron complexes led to clean epoxide product formation using H 2 O 2 as the terminal oxidant. Parallel libraries were used to determine ligand features important for high catalytic activity and to identify enantioselective catalyst structures (see the Equation).