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Covalently Cross‐Linked Watson–Crick Base Pair Models
Author(s) -
Qiao Xiaoxin,
Kishi Yoshito
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990401)38:7<928::aid-anie928>3.0.co;2-o
Subject(s) - molecular structure of nucleic acids: a structure for deoxyribose nucleic acid , watson , covalent bond , base (topology) , base pair , mathematics , chemistry , computer science , dna , natural language processing , mathematical analysis , biochemistry , organic chemistry
Structural characteristics of Watson–Crick hydrogen‐bonded base pairs are displayed by methylene‐bridged base pairs of type A . The shown superposition of the X‐ray structure obtained for the base pair A (Rib 1 =Et; Rib 2 =Me) over that of a C–G base pair illustrates that A occupies an area similar to that occupied by a traditional Watson–Crick hydrogen‐bonded base pair. Temperature‐dependent 1 H NMR studies indicate that the energy barrier for rotation along its CH 2 bridge is about 10 kcal mol −1 , and that it exists predominantly in one conformer at −70°C.