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Functional Molecular Thin Films: Topological Templates for the Chemoselective Ligation of Antigenic Peptides to Self‐Assembled Monolayers
Author(s) -
Scheibler Lukas,
Dumy Pascal,
Boncheva Mila,
Leufgen Kirsten,
Mathieu HansJörg,
Mutter Manfred,
Vogel Horst
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990301)38:5<696::aid-anie696>3.0.co;2-l
Subject(s) - template , supramolecular chemistry , monolayer , molecular recognition , self assembly , nanotechnology , chemistry , regioselectivity , peptide , combinatorial chemistry , materials science , molecule , catalysis , biochemistry , organic chemistry
The combination of self‐assembly and regioselective surface chemistry has made it possible to immobilize peptide recognition sites 1 on a template attached to a gold surface. Each of the seven individual reaction steps, including the final functional biomolecular recognition, was controlled in situ with surface‐sensitive detection techniques. The presented strategy is of general importance for the formation of complex supramolecular structures with biologically interesting functionalities at the interfaces.