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Total Syntheses of Vancomycin
Author(s) -
Zhang Alex J.,
Burgess Kevin
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990301)38:5<634::aid-anie634>3.0.co;2-g
Subject(s) - total synthesis , vancomycin , chemistry , glycopeptide , stereochemistry , combinatorial chemistry , antibiotics , biology , staphylococcus aureus , biochemistry , bacteria , genetics
A total synthesis of the vancomycin aglycon 1 has eluded synthetic chemists for so many years that the preparation of this molecule has become a vendetta for some groups. Finally, and almost simultaneously, research teams led by Evans and by Nicolaou have succeeded. Similarities and differences in their synthetic approaches are highlighted herein.