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A Fully Synthetic Globo H Carbohydrate Vaccine Induces a Focused Humoral Response in Prostate Cancer Patients: A Proof of Principle
Author(s) -
Ragupathi Govindaswami,
Slovin Susan F.,
Adluri Sucharita,
Sames Dalibor,
Kim In Jong,
Kim Hyunjin M.,
Spassova Maria,
Bornmann William G.,
Lloyd Kenneth O.,
Scher Howard I.,
Livingston Philip O.,
Danishefsky Samuel J.
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990215)38:4<563::aid-anie563>3.0.co;2-3
Subject(s) - keyhole limpet hemocyanin , prostate cancer , antigen , antibody , limpet , medicine , cancer , antibody response , immunology , cancer vaccine , cancer research , biology , immunotherapy , gastropoda , ecology
Human trials on the globo H carbohydrate vaccine (see picture, KLH=the carrier protein keyhole limpet hemocyanin) show that it produces strong IgM, and in some cases IgG, responses in patients with progressive and recurrent prostate cancer. Furthermore, these antibodies not only recognize synthetic antigens, but also globo H‐positive tumors in biopsy extracts and tumor tissues.