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Selective RGD‐Mediated Adhesion of Osteoblasts at Surfaces of Implants
Author(s) -
Kantlehner Martin,
Finsinger Dirk,
Meyer Jörg,
Schaffner Patricia,
Jonczyk Alfred,
Diefenbach Beate,
Nies Berthold,
Kessler Horst
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990215)38:4<560::aid-anie560>3.0.co;2-f
Subject(s) - adhesion , osteoblast , covalent bond , chemistry , surface modification , platelet , cell adhesion , peptide , methyl methacrylate , materials science , biomedical engineering , biophysics , in vitro , biochemistry , polymer , polymerization , organic chemistry , immunology , medicine , biology
Osteoblasts: yes, platelets: no! Bone implants have to be integrated with the surrounding tissue to allow a smooth and stable connection. A new procedure is shown which is based on covalent linking of a highly selective RGD peptide to a poly(methyl methacrylate) (PMMA) material (see picture). Osteoblasts very effectively bind to the treated surface and are stimulated to proliferate.