Premium
α ‐Chloroalkylmagnesium Reagents of >90 % ee by Sulfoxide/Magnesium Exchange
Author(s) -
Hoffmann Reinhard W.,
Nell Peter G.
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990201)38:3<338::aid-anie338>3.0.co;2-h
Subject(s) - reagent , magnesium , sulfoxide , grignard reagent , chemistry , combinatorial chemistry , dimethyl sulfoxide , ligand (biochemistry) , metal , inorganic chemistry , organic chemistry , biochemistry , receptor
Not only for ligand exchange at sulfoxides can the sulfoxide/magnesium exchange reaction be used, but it also provides a possibility to generate Grignard reagents in way that avoids metallic magnesium and thus radical processes. Therefore, enantiomerically pure Grignard reagents can be obtained from the corresponding sulfoxides [Eq. (a)].