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Catalytic Enantioselective Reduction of Ketones by a Chiral Gallium Complex and Catecholborane
Author(s) -
Ford Alan,
Woodward Simon
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990201)38:3<335::aid-anie335>3.0.co;2-t
Subject(s) - enantioselective synthesis , reagent , chemistry , gallium , alkyl , catalysis , noyori asymmetric hydrogenation , ketone , organic chemistry , combinatorial chemistry
A catalytically active version of Noyori's famous BINAL reagent Li[AlH(OEt)(BINOL dianion)] is formed by the combination of LiGaH 4 , monothiobinaphthol (MTB), and catecholborane. With this mixture unsymmetrical ketones can be reduced in high enantioselectively. Un=unsaturated unit; R=alkyl.